Study identifies factors that may lower flu vaccine protection

first_imgIn a study designed to identify host and immunologic factors that might affect flu vaccine effectiveness, a research team based in Canada found that genetic changes in circulating viruses, birth year, repeat vaccinations, and waning protection may all play a role. They reported their findings this week in the Journal of Infectious Diseases.They based their findings on an analysis of data from a Canadian surveillance network during the 2015-16 flu season, which was dominated mainly by 2009 H1N1, didn’t peak until March, and had a lot of influenza B activity from the Victoria lineage that wasn’t a component of that season’s trivalent vaccines. Though the circulating H1N1 strain antigenically matched the vaccine, the season saw the emergence of subclade 6B.1. The team compared 596 2009 H1N1 and influenza B Victoria cases with 926 test-negative controls.Overall, vaccine effectiveness (VE) against 2009 H1N1 was 43%, lower than the 71% VE against the strain seen during the 2013-2014 season. Similar declines were seen in the United States and Europe, but they weren’t as steep as Canada’s. VE was also lower in adults born between 1957 and 1976, those vaccinated in both the previous and current seasons, and with a pattern of waning VE later in the season.For influenza B, VE against the Victoria lineage viruses was 54%, adding more evidence of possible cross-protection. And for flu B, researchers didn’t see the variations they saw for 2009 H1N1.They concluded that other factors than just antigenic match may affect vaccine performance, such as shifts in viral genomes, effects of childhood priming and cross-reactive boosting exposure, effects of repeat vaccination, and waning immunity. “Such influences on VE estimates may be daunting to untangle but warrant further in-depth investigation to identify improved vaccine and program options,” they wrote.’Part of a complex web’In a related commentary, Edward Belongia, MD, director of the Marshfield Clinic in Wisconsin, noted several limitations of the study but lauded the comprehensive approach.”The authors clearly acknowledge the limitations of these exploratory analyses,” he wrote. “This was an observational study and power to detect age-stratified effects was low.”Interpretation of birth cohort effects is particularly difficult because year of birth is an imprecise surrogate for imprinting subtype and epitope specificity. An additional limitation of the repeated vaccination analysis is the reliance on self-report and sentinel physician documentation to classify vaccination status in prior seasons.”Belongia, who was not involved in the study, also notes the possibility of poor recall among the patients.He concludes, “Antigenic match remains an important determinant of vaccine effectiveness, but antigenic match alone does not explain why influenza vaccines are predictably less effective than vaccines against other viral infections. It is only one part of a complex web of interactions that include genetic evolution of circulating viruses, gain or loss of glycosylation at key antigenic sites, early childhood imprinting, epitope specificity, egg-induced mutations in high growth vaccine viruses, and the individual immune ‘landscape’ generated by a lifetime of repeated vaccination or infection.”Despite decades of influenza vaccine research, we still do not have a comprehensive understanding of these interactions and how they influence vaccine protection.”See also:Oct 4 J Infect Dis abstractOct 4 J Infect Dis commentarylast_img read more

NATM and Airgas partner to offer discounted welding training

first_imgGet instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270. Subscribelast_img

Two callouts in Cardinia

first_imgBy KATHRYN BERMINGHAM VICTORIA’S hot and windy weather has already caused issues this morning, with brigades called out to two…[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.last_img

Garvey’s Tralee Warriors go top of the Men’s Super League as Swords fall to…

first_imgThe Kerry team now boasts six wins from seven games, having won six in-a-row following an opening round stumble against UCC Demons down at the Mardyke. Garvey’s Tralee Warriors went top of the Basketball Ireland Men’s Super League table on bank holiday Monday, with an 80-71 point win over Éanna at the Complex in Tralee. Griffith College Swords Thunder meanwhile fell at the hands of DCU Saints for the second week in-a-row, losing out 65-69 at the ALSAA.Dee Proby ignited the Saints’ offence as they went down by five against Swords in the fourth, and coupled with strong inside play from Provizors, brought the game back level with just minutes on the clock, and Proby kept a cool head at the free throw line in the dying stages to secure the win.Speaking afterwards, a thrilled head coach, Joey Boylan, was delighted with the result (listen to his full interview here).Elsewhere, Moycullen overcame KUBS in Galway, with a Brandon McGuire inspired home team running out 93-81 point winners in the end, while Lorcan Murphy top-scored with 28 points in Black Amber Templeogue’s defeat of Maree (104-52) at Oblate Hall.You can see a full round up of all the weekend’s games here.View the Men’s Super League table here.Basketball Ireland – Men’s Super League Bank Holiday Monday results (October 30th, 2017)Moycullen 93-81 KUBSTop scorers Moycullen: Brandon McGuire 31, James Loughnane 16, Cian Nihill 15Top scorers KUBS: Brian Andrews 27, Eoin Chubb 16, Shane McCann 8Half time score: Moycullen 45-40 KUBSGriffith College Swords Thunder 65-69 DCU SaintsTop scorers Griffith College Swords Thunder: Isaac Westbrooks 15, Sam Mike 12, Charlie Coombes 12Top scorers DCU Saints: Dee Proby 32, Martins Provizors 14, Emmet Donnelly 7Half time score: Griffith College Swords Thunder 34-39 DCU SaintsBlack Amber Templeogue 104-52 MareeTop scorers Black Amber Templeogue: Lorcan Murphy 28, Neil Randolph 17, Jason Killeen 14Top scorers Maree: Jamal Tolliver 18, Cathal Finn 15, John Burke 7Half time score: Black Amber Templeogue 54-18 MareeGarvey’s Tralee Warriors 80-71 ÉannaTop scorers Garvey’s Tralee Warriors: Trae Pemberton 28, Dusan Bogdanovic 12, Darragh O Hanlon 11Top scorers Éanna: Aidan Dunne 27, Garny Garcia Nivar 26, Tamron Manning 12Half time score: Garvey’s Tralee Warriors 35-30 Éannaprint WhatsApp Facebook Twitter Emaillast_img read more

Joe Canning Wins Irish Independent Magic Sports Moment

first_imgCon O’Callaghan Sweeps Up Young Sportstar of the Year Award & Team of the Year Award Alongside Dublin Teammates The eagerly anticipated and hotly contested Irish Independent Sportstar Awards 2017, in association with The Croke Park Hotel, took place Wednesday evening in the majestic Croke Park Stadium. The star-studded ceremony was attended by over 300 guests including many of the country’s most decorated sports stars as they celebrated another spectacular year for Irish sport, as narrated by the Irish Independent.Irish Racehorse Trainer Aidan O’Brien was the big winner on the night deservedly taking home the title of Sportstar of the Year after his world record breaking season on the track. Cuala and Dublin dual star Con O’Callaghan was named Young Sportstar of the Year, and the 21-year-old also picked up the accolade for Team of the Year alongside his Dublin Senior Men’s Football Panel teammates. The Team of the Year, a new addition to the awards shortlist, is voted for by the Irish public as are all of the awards, with the exception of the Hall of Fame.Irish sporting icon Sonia O’Sullivan was inducted into the illustrious Irish Independent Hall of Fame and, in second of two new awards this year, Galway hurler Joe Canning received the award for Magic Sports Moment for his part in the Tribesmen’s victory over Tipperary in the All-Ireland Semi Final.David Courtney, Head of Sport Content, Independent News & Media said: “We in the Irish Independent are honoured to celebrate yet another enthralling year for Irish sport. This is the 29th edition of the Irish Independent Sportstar Awards and an evening we look forward to each and every year. In Ireland, sport plays a huge part in our culture. It unites us. The passion, the energy, the emotion binds us as a nation, as a community. It is our privilege to support Ireland’s athletes across all sporting disciplines and from achievements at local level through to the world stage. But these awards would not be possible without our loyal readers and for that we are very grateful.”He continued: “The Irish Independent sports desk continuously seeks to deliver the best quality sports reporting to our readers. 2017 was another exceptional year for Irish sport and Irish athletes across the board and we have relished being in a position to showcase their achievements through our multiple platforms. As we celebrate the successes we also look forward to the future and the journey we will continue on together.”As well as the award winners, many recognisable faces and sporting heroes were in attendance at the gala event in Croke Park. Three-time Olympian Eamonn Coghlan was amongst the numerous athletics representatives including Catherina McKiernan. The most decorated GAA player in history Rena Buckely was joined by LGFA Player of the year Noelle Healy as well as other from both ladies football and camogie. Celebrating with him, Joe Canning’s teammate Conor Whelan relived their All-Ireland success whilst the same could be said for Dublin Senior Football Manager Jim Gavin as he watched his team take to the stage. Hockey’s World Goalkeeper of the Year David Harte mingled with young rising stars such as swimmer and one to watch for 2018 Mona McSharry. While former Irish football manager Brian Kerr, Dr. Ronnie Delany and the legendary voice of GAA Mícheál Ó Muircheartaigh were also in attendance. IRISH INDEPENDENT SPORTSTAR OF THE YEAR 2017Aidan O’BrienIRISH INDEPENDENT YOUNG SPORTSTAR OF THE YEAR 2017Con O’CallaghanIRISH INDEPENDENT HALL OF FAME 2017Sonia O’SullivanIRISH INDEPENDENT MAGIC SPORTS MOMENT 2017Joe CanningIRISH INDEPENDENT TEAM OF THE YEAR 2017Dublin Senior Men’s Football TeamJoe Canning winner of the Irish Independent Magic Sports Moment 2017 award pictured at the star-studded 29th Irish Independent Sportstar Awards hosted in Croke Park Stadium in association with The Croke Park Hotel. Photo by Seb Daly/Sportsfileprint WhatsApp Facebook Twitter Email Aidan O’Brien Named Irish Independent Sportstar of the Yearcenter_img 20th December 2017; Joe Canning winner of the Irish Independent Magic Sports Moment 2017 award pictured at the star-studded 29th Irish Independent Sportstar Awards hosted in Croke Park Stadium in association with The Croke Park Hotel. Photo by Seb Daly/Sportsfilelast_img read more

Burges Garners Southland Women’s Tennis Weekly Honors

first_imgFRISCO, Texas – Texas A&M-Corpus Christi senior Sandra Burges has been named the Southland Conference Women’s Tennis Player of the Week, the league office announced Tuesday. Burges, the all-time singles leader in Islanders history, led A&M-Corpus Christi to three conference victories en route to their first Southland Conference regular-season championship. Burges, a senior from Zaragoza, Spain (Marianistas), clinched the match and the title for the Islanders with a 6-0, 6-1, straight-set victory over New Orleans’ Yasmine Rashad in No. 4 singles on Monday. Prior to that, she secured two straight-set victories in No. 5 singles over Abilene Christian and UIW. The senior has powered the Islanders this season with an 18-5 overall record and an 11-1 record in the Southland. Honorable mention this week goes to McNeese State sophomore Klaudia Gawlik, Northwestern State senior Polina Konop, Nicholls sophomore Isla Brock and Abilene Christian senior Micah Hermsdorf.center_img Each school’s sports information director nominates and votes for the players of the week, though is not permitted to vote for his own player. To receive honorable mention, a player must receive votes from 25 percent of the Southland sports information directors.last_img read more

14th Australian Masters Games

first_imgApproximately 8,000 people will travel to Geelong over the next week to take part in the 14th Australian Masters Games. Touch Football is one of 40 sports on offer at the event, with the Touch Football component of the event being held from Sunday, 6 October through to Wednesday, 9 October. The Touch Football competition will see two divisions compete – Men’s and Mixed – at King Lloyd Reserve in Geelong. To keep up-to-date with all of the latest news and results from the Australian Masters Games, please click on the link  Related LinksAus Masters Gameslast_img read more

Jimmy Smits To Be Honored At Moving Families Forward Gala

first_imgLois Braverman, President & CEO, Ackerman Institute for the Family, announced this week that actor Jimmy Smits will be honored with the Ackerman Leadership Award at the Moving Families Forward annual gala which will take place at the Waldorf Astoria Hotel at 301 Park Avenue on Monday, October 26th in New York City.“We are delighted to honor Jimmy Smits with the Ackerman Leadership Award,” says Lois Braverman, President & CEO, Ackerman Institute for the Family. “A born and raised New Yorker, Jimmy understands the needs of his community and is an outstanding example of someone of major success giving back to the next generation. His advocacy of the importance of education and his dedication to providing opportunities and college scholarships for underrepresented Latinos through the National Hispanic Foundation for the Arts, alongside his work with organizations like the Red Cross, New York Cares, and Stand up to Cancer, is a fine example of being of service and making a difference for those most in need.”Jimmy Smits continues to move effortlessly between film, TV and stage. His versatile acting has garnered him critical acclaim and 41 award nominations including wins for both Emmy and Golden Globe Awards.Smits now joins Baz Luhrmann’s music-driven drama for Netflix, The Get Down, as Francisco Cruz, aka “Papa Fuerte”, a South Bronx political boss who delivers services the City fails to provide. New York City serves as the backdrop for what was the birth of hip-hop, punk and disco in the 70s as told through the lives and music of several South Bronx teenagers.Most recently, Smits portrayed Neron “Nero” Padilla in the final three seasons of the much lauded FX show, Sons of Anarchy, introduced in Season 5 as an O.G. (original gangster) and self-proclaimed “companionator,” and an unconventional mentor of sorts for Jax (Charlie Hunnam).In 2010, Smits starred in the NBC drama Outlaw, portraying Supreme Court Justice Cyrus Garza, a playboy and risk-taker who has always adhered to a strict interpretation of the law until he realized the system he believed in was flawed. Smits also served as an Executive Producer on the show. He also co-starred in Mother and Child, directed by Rodrigo Garcia and starring Annette Bening, Samuel L. Jackson and Naomi Watts.Smits has enjoyed an exemplary television career. In 2009, he finished a Guest Starring stint in Season 3 of Showtime’s hit series Dexter, for which he was recognized with his 12th Emmy nomination. In 2008, Smits’ El Sendero Productions company co-executive produced the CBS series, Cane, in which he also starred. He also narrated the PBS documentary series, Latin Music USA. Coinciding with his West Wing Presidency, Smits was also seen in HBO’s multiple award-winning television movie Lackawanna Blues, George C. Wolfe’s colorful tale of boarding house life, love, and blues in 1950’s New York.He received six consecutive Emmy nominations for his role as Victor Sifuentes on L.A. Law, winning the Emmy in 1990, and also five Emmy nominations for his role as Bobby Simone on the critically acclaimed, Emmy-winning drama NYPD Blue. Additionally, he received an ALMA Award and an Imagen Award for Best Actor in The West Wing, has four Golden Globe nominations — winning as an Actor in a Leading Role, Drama Series, in 1995 for his role in NYPD Blue — and four SAG Award nominations. His highly touted departure from NYPD Blue also won the Humanitas Award.Smits’ filmography includes such early works as Peter Hyams’ Running Scared with Gregory Hines and Billy Crystal; John Schlesinger’s The Believers; Old Gringo with Gregory Peck and Jane Fonda; Blake Edwards’ comedy Switch; the critically acclaimed My Family/Mi Familia, directed by Gregory Nava, for which he received an IFP Spirit Award nomination; Carlos Ávila’s Price of Glory; Chuck Russell’s thriller Bless The Child; George Lucas’ Star Wars: Episode II– Attack of the Clones and Star Wars: Episode III– Revenge of the Sith; Robin Swicord’s The Jane Austen Book Club and El Traspatio (Backyard), directed by Carlos Carrera.Smits began his acting career in the New York theater and returns often. In December, 2012, he starred in Stephen Adly Guirgis’s hit play Motherf**ker With The Hat at Chicago’s Steppenwolf Theatre Company. He most recently starred on Broadway in the critically acclaimed hit God of Carnage (2009). Prior to that he starred on Broadway in 2004 as the romantic new arrival in a Cuban-American cigar factory in Nilo Cruz’s Pulitzer Prize-winning play Anna in the Tropics, preceded by the New York Public Theatre’s Shakespeare in the Park presentations of Much Ado About Nothing (2004) and Twelfth Night (2002), just to name a few.Smits has involved himself in various charitable organizations over the years and has consistently been a strong advocate for education. In 1997, he co-founded the National Hispanic Foundation for the Arts (NHFA), along with actors Esai Morales and Sonia Braga and Washington attorney Felix Sanchez, to promote Hispanic talent in the performing arts. The organization offers graduate scholarships and cash grants at prominent colleges and universities in order to expand career opportunities and increase access for Hispanic artists and professionals while fostering the emergence of new Hispanic talent.As previously announced, this year’s other Ackerman Award Honorees are:Alice K. Netter, Ackerman Board Member:· Ackerman Distinguished Service AwardWilliam H. Donaldson, 27th Chairman of the U.S. Securities and Exchange Commission:· Ackerman Partner AwardJacqueline Woodson, National Book Award-winning Author:· Moving Families Forward AwardTamsen Fadal, seven-time Emmy-winning Pix 11 News Anchor, will return to host the evening for the second year running. The event benefits the vital programs and ongoing services for children and families at the Ackerman Institute for the Family. Moving Families Forward Gala Co-Chairs are Martha Fling and Deborah Werner. They are members of the Board of Directors of the Ackerman Institute for the Family, and staunch supporters of its work on behalf of the well-being of children and families of our communities.last_img read more

Toronto stock market Canadian dollar close down slightly as NAFTA talks resume

first_imgTORONTO – Toronto’s main stock market and the Canadian dollar closed slightly lower Wednesday as investors again watched for signs of progress following a resumption of NAFTA talks by Canada and the United States.The political issue of trade again took centre stage, said Allan Small, senior investment adviser with HollisWealth.“A lot is hanging on these talks and what they can accomplish and I think the market right now is basically taking a wait-and-see approach,” he said in an interview.While consumer spending remains strong, corporations are waiting for a decision on NAFTA before making spending decisions, Small added.The S&P/TSX composite index was down 23.73 points to 16,137.57, after reaching a low of 16,032.96 on 219.6 million shares traded. That follows a 108.67-point decline on Friday and a 101.58 point drop on Tuesday.About half of the sectors closed up, led by consumer staples and telecom services. Loblaw Companies Ltd. rose 4.57 per cent to $69.27 a day after the supermarket chain announced it will spin out its real estate investment trust to focus solely on its grocery and pharmacy business.The information technology sector lost almost two per cent as Blackberry Ltd.’s stock fell more than six per cent to $13.15 after Facebook filed a patent infringement lawsuit in U.S. court.The health-care sector had a down day as cannabis stocks lost some ground.In New York, the Dow Jones industrial average was up 22.51 points to 25,974.99. The S&P 500 index was down 8.12 points to 2,888.60, while the Nasdaq composite was down 96.07 points at 7,995.17.Stocks of some of the world’s largest tech names fell as their executives defended their companies in congressional hearings. Twitter’s CEO and Facebook’s No. 2 testified about ways they are trying to root out foreign interference ahead of the midterm elections.The Canadian dollar closed down slightly to 75.84 cents US compared with an average of 75.86 cents US on Tuesday.The loonie barely budged after, as expected, the Bank of Canada decided not to raise its interest rate but signalled another hike could come in October to keep inflation in check.Small said the market is pricing in about an 85 per cent chance that the bank is going to raise rates again.“When the Bank of Canada didn’t move today I think it was expected so I think the dollar held its own.”The October crude contract was down $1.15 at US$68.72 per barrel and the October natural gas contract was down 2.8 cents at US$2.80 per mmBTU.The December gold contract was up US$2.20 at US$1,201.30 an ounce and the December copper contract was up 0.8 cents at US$2.61 a pound.last_img read more

Crushing defeat for Mays deal leaves Brexit path unclear

first_imgLONDON — Britain’s Parliament has delivered a crushing verdict on Prime Minister Theresa May’s Brexit divorce deal, rejecting it by 432 votes to 202 — the biggest defeat suffered by a government in modern British political history.That leaves the country’s EU exit process in crisis, with just 10 weeks until it is due to leave the bloc on March 29.On Wednesday, May’s government faces a no-confidence vote in Parliament. If it survives, May has until the start of next week to come back to Parliament with a Plan B.Here’s a look at what might happen next.TRY AND TRY AGAINAfter Tuesday’s defeat, May assured the House of Commons that “the House has spoken and the government will listen.” She plans to hold talks with lawmakers from across the political spectrum before announcing a new plan.But May’s office has downplayed the prospect of major changes to the deal that has been negotiated, and EU leaders are adamant that the 585-page withdrawal agreement cannot be reopened.That means May could return to Parliament next week with a tweaked deal that is only slightly different to the previous one. But that is unlikely to win over many opponents of the agreement.Tim Bale, professor of politics at Queen Mary University of London, said most leaders who had suffered a defeat on this scale would be “either resigning or looking to trash the deal that they’d got and do something utterly different.”May, however, has proven stubbornly resistant to changing her Brexit “red lines.”“It looks as if we’re just going to get more of the same and that she’ll come back in a week or so’s time with nothing substantially different from what we’ve got now,” Bale said.__DELAY BRITAIN’S EXITParliament has rejected May’s deal, but is split on what to do instead. Some lawmakers want to tack toward a softer Brexit that would see Britain keep close ties to the bloc, while others want to walk away from the EU without a deal.With Parliament split, there is a growing chance Britain will seek an extension to the two-year exit process that is due to expire on March 29.Some ministers are urging May to delay Brexit and then consult lawmakers in a series of “indicative votes” to see if a majority can be found for a new plan. And various factions of lawmakers are exploring ways to use parliamentary rules to wrest control of the Brexit process from the government.A delay would likely also be needed in the event of two other possible scenarios: a general election, or a second referendum. Any delay to the date of Brexit would require unanimous approval from leaders of the EU’s remaining 27 member states.___HOLD AN ELECTIONImmediately after Tuesday’s vote in Parliament, opposition Labour Party leader Jeremy Corbyn called a no-confidence vote in the government, to be held Wednesday evening.If the government loses, Britain is facing an election for a new Parliament and government. The government is likely to survive, however. Almost all members of the governing Conservatives say they will support May, as will her parliamentary allies in Northern Ireland’s Democratic Unionist Party.Labour says it will keep trying to force an election, and could attempt more no-confidence votes in the coming weeks.___SECOND REFERENDUMThe campaign to revisit Brexit in a second referendum — driven largely by supporters of the losing “remain” side in the 2016 referendum — has been gathering steam as the pitfalls and complexity of the divorce process become clear.The government is firmly opposed, but many lawmakers believe a new referendum may be the only way out of the Brexit impasse.But it’s unclear what the question would be. Many pro-EU politicians want a choice between leaving on the proposed terms and staying in the EU, but others say leaving without a deal should also be an option.There’s a strong chance any new referendum would be as divisive as the first.___NO DEALThis is the outcome few want — but it is also the default option. If the divorce deal is not approved, altered or put on hold, Britain will cease to be an EU member at 11 p.m. London time on March 29.The Bank of England has warned that tumbling out of the bloc with no deal to soften the exit could plunge Britain into its deepest recession in nearly a century, and businesses warn the sudden end to longstanding trading agreements with the EU could see gridlock at British ports and shortages of food and medicines.___Follow AP’s full coverage of Brexit at: Lawless, The Associated Presslast_img read more